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Research Chemicals (RC) are psychoactive substances, either derived from variations in the molecular structures of existing illegal substances , or more rarely, entirely new structures but with effects similar to drugs already known. 

The reason for the production of these substances is mainly related to the desire to circumvent existing laws. The best-known RC is undoubtedly mephedrone , which hit the headlines in 2010 and was later classified as a narcotic in most countries.

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The use of the term Research Chemicalemerged in the 1990s in the USA from a number of internet vendors claiming to sell a variety of psychoactive chemicals (many of which were analogues of scheduled chemicals) for legitimate research purposes. 

The vendors believed that this marketing strategy would allow them to avoid prosecution under the US Federal Analog Act, which is an amendment to the US Controlled Substances Act (effective 1986). 

According to this law, any chemical that is functionally and structurally "substantially similar" to a Schedule I or II controlled substance can be treated the same way, but only if the prosecutor can demonstrate intent for human consumption.

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This is why we see “ Not for human consumption ” flourishing on sales sites . This allows the seller to avoid lawsuits in the USA, Germany and perhaps elsewhere!

Consumption patterns

The modes of consumption are as diverse as the molecules. RCs are taken orally, by snorting, while smoking, or by IV or intramuscular injection. In any case, it is strongly advised to test RCs by sniffing or orally. The effects (and therefore the dosages) differ greatly from one mode of consumption to another.


The RC sniff can be very aggressive for the nasal mucous membranes. It is rather advisable to consume them by parachute .

It is not possible to describe the effects of each RC. Depending on their categories, they have empathogenic effects (Substance inducing a feeling of empathy with others), psychedelics (hallucinations and inner research), stimulants, calming... barbiturates (etaqualone), or even synthetic cannabinoids (AM2201 , UR-144...). 

The whole panoply of "old" drugs to its equivalents in RC. CR can have (approximately) the effects of MDMA (5-APB, MDAI..), LSD (5-meo-dalt, 2-CB), amphetamines (2-AI, ethylphenidate, camfetamine, AMT) ketamine (N-ethyl-ketamine, methoxetamine), methamphetamine (methiopropamine), can be opiates (AH-7921, desoxy-tramadol...), benzodiazepines (etizolam)...

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However, here are some RCs with their desired effects and dosages:


6-APB or benzofury (trade name)

Molecule: 1-benzofuran-6-ylpropan-2-amine

Family: phenethylamine/amphetamine.

Dosage: Oral route: 80mg to 130mg in a single dose. (indication)

Effect: Rise 1 to 2 hours but imperceptible. Tray minimum 4h. Entactogenic and sociable. Descent clenching of teeth and slight muscle spasms. Inability to sleep within 12 to 16 hours of taking.

Note that under the name benzofury there are pills dosed at 125mg of 6-apb, and apb pellets at 60mg6-apb/60mg5-apb

See also the trip report of Onicks TR 6-apb benzo fury: 150mg pellet in redrop outdoor

2C-B-FLY

Molecule: 1-(8-bromo-2,3,6,7-tetrahydrobenzo[1,2-b:4,5-b']difuran-4-il)-2-amynoetanol

Family: 2-Cx. There is a wide variety of combinations of 2C-(X). For example, 2C-C or 2C-D. These derivatives have an effect similar to that of 2C-B-Fly, but differ greatly with respect to dosage and duration of action.

Dosage: 10 mg (oral) (as 2C-B) (indication)

Effects: rise after 90 minutes, duration from 6 to 15 hours. 2C-B-FLY is a psychedelic drug, the effect of which has been described as very similar to that of 2C-B, but with a more intense emotional component.

Metoxetamine or MXE

Molecule: 3-MeO-2-Oxo-PCE

Family: arylcyclohexylamines (close to ketamine)

Dosage: Oral route: threshold of 8 to 20mg, 40 to 60mg in a single dose (indication).

Effect: Effects and side effects are similar to that of ketamine. By oral route: rise after 10 to 20 minutes, plateau between 1 to 2 hours.

risk to be aware off

No retreat

Unlike drugs such as heroin, cocaine or alcohol, we do not know the medium and long term effects of CR. The hypocrisy of "Not for human consumption" and the constant renewal of molecules means that no one has the time to really experiment or research these products and the risk reduction associations do not have the time to share clear and independent information.

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Little by little studies are made, well after the first use and we learn that in England for example with mephedrone 51% of mephedrone users would have suffered from headaches, 43% from heart palpitations, 27% from severe nausea and 15% had frozen or blue fingers.  

With methylone or "M1" (very toxic for the brain) many trip report persistent ant-like sensations in the skull, or deep mental confusion after the trip, even amnesia, having required hospitalizations.


No control

The other main danger of RCs is that they are not controlled. When you order an RC on the internet, you never really know what you will receive , nor the percentage of active product, nor the impurities contained in these substances following a bad synthesis (example: MPTP in desmethylprodine ), nor even if it is the right molecule.


A lot of RCs are made on the fly in labs in China that aren't fussy. The story of the death of a Danish salesman in October 2009 is revealing in this respect [15]. At the end of September, Dannie Haupt, an RC salesman, received a shipment of what he believed to be 2-CB-Fly from his Chinese supplier. 

Without analyzing the product, Dannie Haupt decides to take 18mg, and dies a few hours later from respiratory depression. But during this time, he sells several doses to these customers around the world. 

Another death in the USA and several cases of hospitalization are then reported. An analysis of the substance a few weeks later shows that Dannie Haupt's shipment is not 2-CB-Fly, but bromo-dragonFLY, whose active dose is in the microgram range. Dannie Haupt fatally overdosed.


Serotonin syndrome

Like MDMA, many CRs can induce "serotonin syndrome" (a potentially fatal disorder of the chemical balance of the central nervous system due to an excess of serotonin in the brain.) which can be fatal in the event of an overdose. some of these molecules and/or mixtures with other drugs or foods.


" The risk is particularly high on mixtures inducing the taking of an MAOI product. Some anti-depressants are part of it but not only. For example, 2C-T-7 is MAOI, aMT is MAOI... Mixing an MAOI and a product that acts on serotonin means exposing oneself to a very high risk of serotonin syndrome that can lead to death.

Mixing two products that simply act on the seroto in a classic way can also induce a seroto syndrome with dosages that are not revised downwards. 

Attention for example with the MXE. If the Keta/MDMA combo is deemed to be quite "safe" physically, the same is not true of the MXE/MDMA combo because if the Keta does not act on the seroto, the MXE does.

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What you need to know with Syndrome S is that it can manifest itself in more or less violent forms. Most often, it is in its less violent forms that we assimilate most of the time to a lambda side effect. 

I speak here knowingly, because a few years ago, I suffered from several symptoms of SS (at the time I did not know it was one) and I had to consult several doctors and then specialist (ENT, Ophthalmologist then finally neurologist). 

I suffered from brainzaps (those famous dizziness that assails you when you sleep or even all the time for several weeks in my case), from hypersensitivity to fast-paced images and to sounds. A neurologist finally explained to me that this was one of the symptoms of an SS


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