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Synthetic cannabinoids are synthetic molecules that act in a way similar to that of plant cannabinoids, naturally present in cannabis (such as THC)

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They are primarily cannabinoid receptor agonists. Most were developed for therapeutic purposes (analgesia), others were synthesized with the aim of creating legal alternatives to cannabis.

Synthetic cannabinoids are the most important class of new synthetic products . Of the 73 new synthetic substances reported by the EMCDDA in 2012, 30 were synthetic cannabinoids. From 2008 to May 2013, 84 synthetic cannabinoids were reported by the European alert system.

According to the 2014 Barometer, 1.7% of 18-64 year olds have already consumed synthetic cannabinoids in France. (Similar level of use to heroin)

The first "synthetic cannabis" was in the form of a mixture of various plants that had been impregnated with synthetic cannabinoids. It appeared in the mid-2000s as Spice  ( Spice Gold , Spice Silver ...). Other brands then appeared ( K2 , Yucatan Fire , etc…). These products only really gained popularity from the second half of the 2000s.

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nb= For those who knew the saga of "Dune" by Franck Herbert, the name "Spice" was given in reference to the "Spice" of the science fiction novel, the spice produced by the planet Arrakis, which increased the psychic abilities and allowed interstellar travel, for example.

At the end of 2008, analyzes detected the presence of synthetic cannabinoids in these mixtures, in particular CP-47,497-C8 and JWH-018. Following measures to ban these compounds in several countries, manufacturers will then use new molecules. In 2009, other synthetic cannabinoids such as JWH-073, JWH-019, JWH-250, JWH-398 and HU-210  will be identified . Other new compounds will be regularly identified thereafter.

Composition

Most of the synthetic cannabinoid powders that are used in “legal highs” are manufactured in China and then shipped in bulk through legal transportation and distribution networks. Shipments of several kilos are often intercepted by European authorities, but purity is rarely determined. A study in South Korea reported purities between 75% and 90% on bulk powder samples. European seizures of bulk powders include 54 kilograms of JWH-018 in Denmark (2012), 21 kilograms of JWH-018 in Finland (2012) and 20 kilograms of AM-2201 in Spain (2013).

Once in Europe, the products are mixed with herbs. This form is primarily intended for smoking. Among the herbs used as a carrier, the following species can be mentioned: Canavalia maritima , Nymphaea caerulea , Scutellaria nana , Pedicularis densiflora , Leonotis leonurus , Zornia latifolia , Nelumbo nucifera or Leonurus sibiricus 

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Other types of substances have also been identified in some samples:

• fatty acid derivatives with effects similar to cannabinoids: oleamide, palmitamide, stearamide
• MAOIs: harmine, harmaline
• an opioid: O-desmethyltramadol
• other molecules, some of which come from the plants used as a support and others which would have been added

Today, CS is no longer found only within herbal smoking blends but can be obtained as an isolated powder from some RC suppliers. They can also be found in resin form (like the Bang Solid or Afghan Insense brands) in response to the growing popularity of cannabis resin in many countries. It can also be found in some e-liquids for electronic cigarettes.

Chemistry and names of synthetic cannabinoids

Many of the synthetic cannabinoids have code names that relate to their discovery. In some cases, their code name comes from the initials of the name of the scientists who first synthesized them: the "JWH" compounds come from John W. Huffman, the "AM" compounds come from Alexandros Makriyannis. In other cases, they may come from the company where they were synthesized: the “HU” series comes from the Hebrew University of Jerusalem, the CP series was created by the Pfizer laboratory.

Others may have codenames derived from their chemical name: APICA for N-(1-adamantyl)-1-pentyl-1H-indole-3-carboxamide or APINACA for N-(1-adamantyl)-1-pentyl -1H-indazole-3-carboxamide

More recently, those involved in the "legal high" business have started using code names that were likely chosen to help market the products. For example, AKB-48 is another used name of APINACA. AKB-48 is the name of a popular Japanese girl group that has been compared to British pop group 'Spice Girls'. The synthetic cannabinoid APICA is also referred to by the alternate name of "2NE1", which is the name of a South Korean girl group that has also been compared to the Spice Girls. Finally, the synthetic cannabinoid XLR-11, appears to have been named after the first liquid fuel developed in the United States for use in airplanes.

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Synthetic cannabinoids have various structures. We can distinguish 

THC and some examples of CS

• Naphthoylindoles:

JWH-007, JWH-015, JWH-018, JWH-019, JWH-073, JWH-081, JWH-098, JWH-116, JWH-122, JWH-149, JWH-182, JWH-193, JWH- 198, JWH-200, JWH-210, JWH-398, JWH-424, AM-1220, AM-1221, AM-1235, AM-2201, AM-2232, MAM-2201

• Benzoylindoles:

AM-630, AM-679, AM-694, AM-1241, AM-2233, RCS-4

• Phenylacetylindoles:

JWH-167, JWH-203, JWH-250, JWH-251, JWH-320, RCS-8

• Cyclohexylphenols:

CP-47,497, cannabicyclohexanol (or CP-47,497-C8), CP-55,490, HU-308

• Naphthylmethylindoles:

JWH-175, JWH-184

• Naphthoylpyrroles:

JWH-030, JWH-147, JWH-307

• Naphthylmethylindenes:

JWH-176

• Adamantoylindoles:

AB-001, AM-1248

• Cyclopropanoylindoles:

UR-144, 5F-UR-144 (or XLR-11), A-834,735, A-796,260

• Other synthetic cannabinoids:

HU-210,HU-211,WIN-55,212-2

Dosages

The dosages differ from one compound to another, so it is advisable to find out about the dosages before consumption. Many synthetic cannabinoids exhibit significantly higher potency than THC. It can be twice higher (for the CP 47.497 and the C6), 4 times higher (for the JWH-018) or even 200 times higher (for the HU-210). Thus, the usual doses and the quantity of powder can be less than 1mg.

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But, in practice, we must warn about the consumption of cannabinoids, which is much more dangerous than that of cannabis. In particular, because the exact composition of the product is generally unknown or badly known. But, even when it is known, these are potentially dangerous products and should be avoided. The best way to reduce accidents due to synthetic Cannabinoids would be the "liberation" of cannabis. In addition, this would allow you to choose your cultivars according to the expected effects and the RdR.

Effects

Depending on the cannabinoid, the duration of the effects is very variable from one molecule to another. It is more or less long than that of THC. Some minor symptoms may persist for up to 24 hours after taking. So regardless of the affinity to CB1 receptors, some cannabinoids can have a long half-life and cause a prolonged psychoactive effect (very different from cannabis)

" On a personal basis, because the effects and feelings may vary from one person to another.

MMB-Chminaca and MMB-Chmiza are downers.

5F-PB22, Fub-PB22 and AB-Pinaca have a psychedelic bent.

5F-AKB48 , AB- Fubinaca , 5F-ADB have more of a pure sativa effect with a pronounced psychic high.

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The THJ018 and 021, the STS135 and the JWH122 make me think of... The effects of a powerful shit. At least initially because the phenomenon of tolerance appears very quickly and once installed, the effects disappear almost entirely.

Some combos can approach the effects of certain herbs.

Keeping in mind that these are Noids and have little to do with the plant (there is a risk of overdose with Noids that does not exist with weed or weed ).

Also check: research chemicals post

HU210 Guide